From the "Trail of Tears" to Wounded Knee and Little Bighorn, the narrative of American history is incomplete without the inclusion of the Native Americans that lived on the continent before European settlers arrived in the 16th and 17th centuries. Since the first contact between natives and settlers, tribes like the Sioux, Cherokee, and Navajo have both fascinated and perplexed outsiders with their history, language, and culture. In Charles River Editors' Native American Tribes series, listeners can get caught up to speed on the history and culture of North America's most famous native tribes in the time it takes to finish a commute, while learning interesting facts long forgotten or never known.

The Seminole tribe is one of the best known Native American tribes, and one of the most feared among 19th century Americans and Spaniards. In fact, the origin of the term Seminole comes from a Spanish description of them as "wild", which belies the fact that the Seminole had friendly relations with the British and Spanish during the colonial era.

With the Spanish Empire foundering during the mid-19th century, the young United States sought to take possession of Florida. President Andrew Jackson's notorious policy of Indian Removal led to the Seminole Wars in the 1830s, and that was already after General Andrew Jackson had led American soldiers against the Seminole in the First Seminole War a generation earlier. The Seminole Wars ultimately pushed much of the tribe into Oklahoma, and the nature of some of the fighting remains one of the best known aspects of Seminole history among Americans.